FIELD(S) OF ACTIVITY:
Academic and research in bioengineering, biomedical sciences, rehabilitation
RESEARCH PRIORITIES:
bioelectromagnetism,
physiological signals,
e-health and telemedicine,
tissue engineering and biotechnology,
nanotechnologies,
rehabilitation
INNOVATIVE RTD ASPECTS:
technologies supporting diagnostic and intervention;
nanotechnologies,
bioelectromagnetism
COOPERATION INTERESTS:
undergraduate and master level academic exchanges;
research collaboration under FP 7 program - bioelectromagnetism, physiological signals, e-health and telemedicine, tissue engineering and biotechnology, nanotechnologies, rehabilitation;
research under bilateral programs.
REQUESTED PARTNER PROFILE:
universities - departments of bioengineering, applied engineering, medical engineering, rehabilitation, biotechnologies, materials science
research institutes – bioengineering, applied engineering, medical engineering, biotechnology, rehabilitation, materials science
companies – medical and pharmaceutical products
Department: Laboratory of Immunology and Genetics, Interdisciplinary Platform of Molecular Medicine
FIELD(S) OF ACTIVITY:
Cell culture, flow-cytometry, immunohistochemistry and digital image analysis immunoserology, histocompatibility HLA-phenotyping, fluorescence mycroscopy, caryotyping, FISH, molecular biology and molecular biochemistry
RESEARCH PRIORITIES:
prenatal genetic and molecular diagnostic,
molecular study of genetic predisposition to cancer, microenvironment of cancer tissue development,
bone marrow microenvironment in dysplastic syndromes,
leukaemia and multiple myeloma, inflammation.
Keywords specifying the expertise:
Breast and colon cancer, trophoblast-decidual interaction in pregnancy pathology, Histocompatibility, Cell culture, Flow-cytometry, Immunopfenotyping in hematological malignancies, Tissue Faxs, Intracellular cytokine detection, Cancer angiogenesis, Caryotyping, PCR and RT-PCR, DNA sequencing.
Description of the expertise:
Breast cancer inflammatory infiltrate, Breast cancer lymphangiogenesis, Colon cancer and hepatic metastases, Immune function at the decidual-trophoblast interface, Hereditary Breast and Ovarian Cancer (HBOC) families identification and recruitment, blood sampling, DNA extraction and sampling, mutiplex-PCR detection of known mutations, DNA sequencing, and genetic counseling of BRCA mutations concerned families, Bone marrow microenvironment in multiple myeloma.
Experience in international cooperation and partnership:
Ludwig Albert University and Medical Center of Freiburg, Germany
Universite Auvergne, Clermont-Ferrand, France
Centre d’Oncologie Moleculaire Jean Perin, Clermont-Ferrand, France
Unite INSERM U774, Lille, France.
REQUESTED PARTNER PROFILE:
cancer molecular biology and oncogenetics,
molecular genetic diagnostic,
molecular immunology.
Department: Cell Physiology and Pharmacology Lab Contact person: Serban Dragomir Conf. Dr.
e-mail: dnserban@yahoo.com
FIELD(S) OF ACTIVITY:
vascular biology,
neuroscience
RESEARCH PRIORITIES:
cytosolic calcium signals,
ion channels and membrane potentials,
mechanisms of smooth muscle contraction,
endothelium-dependent relaxation
INNOVATIVE RTD ASPECTS:
activation and role of store-operated calcium-channels,
changes in the profile of mechanisms that ensure endothelium-dependent relaxation in physiological and pathological conditions
COOPERATION INTERESTS:
microelectrophysiology of primary and secondary sensorial neurons (esp. involved in pain),
experimental arthritis in rats
possibility of technical training (4-6 months) for one young investigator who will also get involved in a research project in the host lab.
REQUESTED PARTNER PROFILE: expertise in one of the ‘interests’ above.
Department of Pharmacology-Algesiology and Center for the Study and Therapy of Pain
Contact person: Director Professor Ostin C. MUNGIU, MD, PhD
e-mail: ocmungiu@yahoo.com
FIELD(S) OF ACTIVITY:
Study and Therapy of Pain
RESEARCH PRIORITIES:
Mechanisms involved in the production, transmission, perception and control of pain, in both physiological and pathological conditions
INNOVATIVE RTD ASPECTS:
Multi- and trans-disciplinary approach to investigate the mechanisms of peripheral and central nociception, from the systemic (organism) level down to their cellular and molecular basis, including:
Micro-electrophysiological studies upon the neuronal circuits involved in pain modulation
Studies on the pharmacological modulation of nociception of various etiologies:
Nociception behavioral studies and electrophysiological studies to clarify the role of various receptors neuronal ionic channels in pain the mechanism of action for anti-hyperalgesic agents that interact with these receptors and channels.
Assessing the importance of the inflammatory component in activation of peripheral opioid receptors.
Multi-parameter studies on the manner in which certain analgesic compounds affect the mechanisms of smooth muscle contraction and upon the implications of vascular phenomena in nociception.
Assessing the importance of the immune system and its inter-relation with glial cells in neuropathic pain using behavioral, imunohistochemistry and ELISA investigations
Clinical studies on markers/methods to improve prediction/treatment of neuropathic pain
Use of advanced molecular modelling to obtain predictive three dimensional molecular models for receptors/channels involved in pain (Kv7, TRPV1, NMDA, mGluR, opioid) and their complexes with natural/synthetic agonists/antagonists
COOPERATION INTERESTS:
Pharmacokinetic and pharmacodynamic optimization for drugs used in pain therapy, by using novel drug-delivery systems based on smart carriers (i.e. nanocarrier systems) for controlled and/or targeted drug delivery.
Dose-efficiency, quality of life and therapeutic interactions report evaluations for opioid and non-opioid analgesic drugs.
Epidemiology of pain and pharmacoepidemiology of pain therapy.
Clinical trials for novel analgesic agents.
REQUESTED PARTNER PROFILE:
Research and development organization (Academic, Private, Government) with extensive expertise in one or more of the following fields: chemistry, biochemistry, nanotechnologies, clinical areas (neurology, rheumatology, oncology), drug design, analgesic drugs.
