Stage 2019:

Metal-complexes of modified indolo[2,3-c]quinolines and new indolo[3,2- d]benzazepines

Specific aims:
-> Synthesis of metal-based indolo[2,3-c]quinolines and new indolo[3,2-d]benzazepines
-> Purification and characterization of the obtained metal complexes
-> Studies on solution equilibria and hydrolytic stability of the proligands and metal complexes in biological environments
-> Study of antiproliferative activity of proligands and metal complexes in several cancer cell lines and normal cells
-> Dissemination of the results

Deliverables: Stage 2019: At least four well-defined metal complexes based on new indolo[2,3-c]quinolines and indolo[3,2-d]benazepines containing metal-binding sites; results of antiproliferative activity assays for four proligands and four metal complexes; at least one research article submitted at an ISI journal; Scientific Report.