The project proposes the obtaining, characterization and testing of the responsive character, biocompatibility and applicability of some new polymeric materials multi-stimuli responsive to the action of externaal agents. In order to achieve this goal a complex comparative experimental protocol will be applied to three responsive macromolecular structures/architectures, namely: 1) interpolymeric complexes, 2) grafted copolymers 3) hydrogels, potentially applicable to develop new medical terapies with direct results both to improve population health and to apply them in advanced technologies.
     The obtaining of the "inteligent" polymeric materials will be achieved by non-polluting procedures, by a strategy based on renewable biodegradable compounds (polysaccharides: alginate and chitosan) known by their geling and antimicrobienne properties and a synthetic polymer - poly(N-isopropylacrylamide);  the biopolymer will be synergic combined  with the other by chemical and physical ways and the behaviour of the materials under the action of temperature, pH, electrical charge, biological molecules, will be studied. The expected peculiar behaviour will determine their responsive character in the controlled delivery of biologically active principles, as biosensors, etc. The obtaining of new inteligent nanoparticulate therapeutic systems polymeric material/active principle is the second step which includes in vitro and in vivo testing and possible large scale transfer of the results. All these will be achieved by members of the group with related activities included in 4 PhD theses and a post-doc one.  The project is complex, it has an interdisciplinary character and double role to increse the competitivity of the romanian research and to enrich the knowledge in the field by a deeper understanding of the living organisms functions.
     Dissemination of the results is assured existing 5  external partenership collaborations, 3 FP7 proposals to develop our original procedures and methods.